Cross-trait heritability for asthma and allergy

We used UK Biobank (UKBB) data field 6152 as our doctor diagnosed asthma and allergic disease (hay fever, allergic rhinitis or eczema) phenotypes. This data is generated from UKBB application #16549.

Data field 6152 contains a question from touchscreen for the participants to answer: “has a doctor ever told you that you have had any of the following conditions? (You can select more than one answer): Blood clot in the leg (DVT); blood clot in the lung; emphysema/chronic bronchitis; asthma; hayfever, allergic rhinitis or eczema; none of the above; prefer not to answer.

GWAS single SNP summary statistics for asthma

GWAS single SNP summary statistics for allergic diseases

Header of table
CHR	Chromosome
SNP	SNP identifier
POS	Physical position (base-pair) hg19
A1	Tested allele (minor allele by default)
OR	Odds ratio for tested allele
SE	Standard error
STAT	t-statistic
P	p-value

Citation: Zhaozhong Zhu, Phil H. Lee, Mark D. Chaffin, Wonil Chung, Po-Ru Loh, Quan Lu, David C. Christiani, Liming Liang (2018) A genome-wide cross trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nature Genetics. 2018 June ; 50(6): 857–864.

By Liming Liang's Lab at Harvard T.H. Chan School of Public Health